Learn how allergies happen, how they affect your horses body, and how to avoid or treat them. 9. For this first stretch, thats not going to get me too far since I need the loading dose up front. Many allergic reactions are evident as a mild case of transient hives. 20. It generally reduces itching very quickly within 24 hours and is felt to be as effective as corticosteroids. Please select your state below. Apoquel for horses - Horse Care - Chronicle Forums Since oclacitinib has been shown to be comparable to prednisolone, oclacitinib can be a good alternative to prednisolone when combined with cyclosporine for initial treatment. But the immune system is not a perfect one. Treatment success in three Andean bears (Tremarctos ornatus) with alopecia syndrome using Oclacitinib maleate (Apoquel). Panteri A, Strehlau G, Helbig R, et al. We. test dose in your pet before long-term use, espe- cially in horses. Immunomodulatory in vitro effects of oclacitinib on canine T-cell proliferation and cytokine production. "Even though the drug is currently labeled for use in dogs (with. Apoquel is the brand name of oclacitinib, a dog medication designed to relieve itching associated with allergies in dogs, particularly canine atopic dermatitis. If your horse has "classic" RAO, he may have more difficulty in the barn, and need to be kept outside 24/7.3: The Supplements: Studies have shown that horses with Asthma benefit from supplements with Omega 3 fatty acids. Vet Dermatol 2016;27(Suppl 1):84 (abstract). While this is a very important strategy for some types of Equine Asthma ("classic" RAO), it may not be as important when managing those with Summer-Pasture-Associated disease. Binding of these cytokines to their receptors activates the JAK-STAT (signal transducers and activators of transcription) pathway, which leads to further cytokine production.1 In recent studies, IL-31 has been shown to play an important role in pruritus, and elevated serum levels of IL-31 have been found in many atopic dogs.2, There are 4 JAK families in mammals: JAK1, JAK2, JAK3, and TYK2. Oclacitinib preferably inhibits JAK1 and, to a lesser degree, JAK3, resulting in decreased activity of JAK1-dependent cytokines involved in allergy and inflammation (IL-2, IL-4, IL-6, and IL-13) as well as pruritus (IL-31).4. Apoquel - Lodi Veterinary Care actually treats degenerative joint disease (DJD), not just its clinical signs. Read on below! I actually have 2 horses now on serum and one I eliminated the food specific allergens from his diet. If signs . However, the study showed that cyclosporine caused a 3-fold higher risk for developing gastrointestinal side effects (vomiting and diarrhea) compared with oclacitinib.12, Despite its delayed effects, cyclosporine is still a popular drug to treat canine atopic dermatitis because in some cases it can be dosed every other day or even every third day after initial daily treatment. Apoquel For Cats: Dosage, Safety & Side Effects - Cats.com Apoquel Overdose Information Dogs that received overdoses in safety studies had side effects that included one or more of the following: vomiting, diarrhea, cysts between the toes, skin inflammation, papilloma's (warts), pneumonia, enlarged lymph nodes, and decreased blood cell production. Renal Anemia, or . It is absolutely miraculous for these itchy miserable horses. Treatment should be started at a dose of 0.4 - 0.6 mg per kilogram bodyweight twice a day for up to two weeks. Pros and cons of oclacitinib therapy. The concentration of the drug is 500 mg/ml. 1. Until recently, glucocorticoids (systemic and/or topical) and cyclosporine have been considered the most effective symptomatic treatment options to manage atopic dermatitis.5 Oclacitinib is now also an effective option (BOX 1). The tablets come in three dose sizes: 3.6mg 5.4mg 16mg Always give the dose prescribed by your veterinarian. Binding of these cytokines to their receptors activates the JAK-STAT (signal transducers and activators of transcription) pathway, which leads to further cytokine production. Do not use Apoquel in dogs less than 12 months of age or those with serious infections. For atopic and allergic dermatitis, Apoquel may be given to dogs at a dosage of 0.18 - 0.27 mg/lb. For the first two weeks, this is to be given twice per day, and then once per day after the first two weeks for maintenance. These can be severe and lead to a life-threatening, airway-blocking, whole-body reaction called anaphylaxis. 405 HERON DRIVE SUITE 200 SWEDESBORO, NJ 08085-1749 | 2004-2023 WEDGEWOOD PHARMACY, ALL RIGHTS RESERVED. A blinded, randomized, placebo-controlled trial of the efficacy and safety of the Janus kinase inhibitor oclacitinib (Apoquel) in client-owned dogs with atopic dermatitis. Vercelli A, Cornegliani L. Use of oclacitinib in treatment of canine idiopathic ear tip vasculitis. 27. Equine Asthma- yep, that's the new name for "heaves," "RAO," "COPD" or whatever else we've called it over the years! In fact, in our recent study evaluating almost 400 potential allergens, latex proteins were the most significant allergens for diagnosing severe equine asthma.. But I had my mare tested last year, she also came up allergic to some foods (flax being one) for which I was told serum was not an option. A blinded, randomized, placebo-controlled trial of the safety of oclacitinib in cats. Side effects have been rarely seen and documented, but the most common occurrences have been mild vomiting and diarrhea. As a result, muscles relax and cause heavy sedation, notes DailyMed. She would be a scratching mess without it. For dogs weighing between 10 and 14.9 pounds, give of a 5.4 mg tablet twice daily as dosage. Left untreated, these conditions can not only cause discomfort but also lead to raw, broken skin that allows bacteria to invade and infect. Posted by Lucile Vigouroux | May 4, 2022 | Article, Diseases and Conditions, Farm and Barn, Hives & Skin Allergies, Horse Care, Medications, Nutrition, Seasonal Care, Skin Problems. My understanding from my vet and from what Ive read is that in horses theres been a lot of success in spacing out the dosing, but not as much success in lowering the dose amount. Apoquel 16 mg tablets for Dogs (Canada) - Drugs.com Interleukin-31: its role in canine pruritus and naturally occurring canine atopic dermatitis. An antibody called immunoglobulin E (IgE) is produced when the body detects an allergen, says Samuel White, PhD, a professor of equine science at Nottingham Trent University, in England, known for his research on allergen identification and diagnostic development in the horse. Vet Dermatol 2015;26(1):23-30, e7-8. It is most risky in horses that have metabolic disease like Equine Metabolic Syndrome (insulin resistance), PPID (cushings), or those that are overweight. Allergies primarily affect the immune, respiratory, and integumentary (skin) systems and, if unmanaged, can seriously impact an animals performance and well-being. No texts please., Horse breeding from planning through foal care, Horse-health-problem risk factors, prevention, diagnosis, and treatment, Design and maintain a healthy horse operation, Prevention and treatment for problems of the equine foot, How to care for the basic health needs of horses, Prevention, diagnosis, and treatment of leg lameness, Proper feeding practices for foals, adult horses, and older horses, All aspects of caring for performance horses, News and issues for equine health professionals, Discussions about the welfare of our equine friends. So new drugs such Atopica and Apoquel are prescribed routinely, to help dog owners find a quick fix for dog allergies. Apoquel Prices, Coupons & Savings Tips - GoodRx Recently, one group has looked into immunomodulatory properties of oclacitinib by observing canine T-cell proliferation and cytokine productions in vitro. Luckily most of her allergies appear to be insect-based and she responds very well to the serum for that. on various factors. Apoquel 16 mg, 20 Ct. | Free Shipping | EntirelyPets Rx How to Manage Equine Asthma (RAO or Heaves) - Foundation Equine Clinic The anti-inflammatory/immunosuppressive response is confined almost exclusively to the lungs, avoiding a bodywide effect, says Fultz. All product and company names are trademarks or registered trademarks of their respective holders. 30. Drake GJ, Nuttall T, Lpez J, et al. Vomiting, diarrhea, and lack of appetite are also possible. Olivry T, Banovic F. Treatment of canine atopic dermatitis: time to revise our strategy? This makes it a common site for the bodys expression of allergic reactions. The drug targets pro-inflammatory proteins, called cytokines, responsible for itching and inflammation, relieving signs of skin allergies. has been administered by veterinarians to help horses of . Having allergy tested 3 horses you can get a serum for some allergens but not all. If the horse is allergic to any of them, his immune system elicits a response, and a hive forms at the injection site. I have not tried to go less than that. Intradermal allergy testing is the gold standard for this and involves a veterinary dermatologist subcutaneously injecting very small quantities of potential allergens into a clipped patch of the horses neck. Allergen avoidance and allergen-specific immunotherapy are measures that address the allergy itself; various drugs are available for symptomatic management. 1,2 The #1 prescribed medicine for allergic itch in dogs. Your veterinarian might also prescribe corticosteroids such as dexamethasone or prednisolone, which provide fast and effective relief from immune-mediated conditions such as allergies because of their immunosuppressive properties. Although no studies of pharmacokinetics in cats have been published, oclacitinib is well tolerated and seems to be safe when used in cats at 1 or 2 mg/kg q12h for 28 days.21 Further studies are needed to investigate adverse effects associated with long-term use in cats. Cosgrove SB, Cleaver DM, King VL, et al. However, a small subcategory of asthmatic horses suffer from pasture-associated equine asthma. Apoquel (oclacitinib) | PetMD There are two types of this condition, summer-pasture-associated and classic recurrent airway obstruction (RAO). 3 Can be used for long-term maintenance or short-term therapy in dogs 12 months of age . Apoquel For Dogs - Apoquel Uses, Side Effects And Dosage Explained The steroids are usually given orally, but we may want to start with injections for a week or so in severely affected horses. Yamaoka K, Saharinen P, Pesu M, et al. I did not know about this, but considering Im going through apoquel at a reasonable rate this sounds like it would be worth signing up for. Safety & Side Effects Apoquel is safe to use in dogs one year and older. At that point, the treatment can be changed to oclacitinib. Fultz adds that over time this process teaches the immune system to tolerate exposure to substances it previously considered irritating. Oclacitinib (APOQUEL) is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. I was one of the veterinarians involved in early field trials for Apoquel in horses. K. Route of Administration . Vet Dermatol 2014;25(6):512-518. 2022 Zoetis Services LLC. Apoquel is the #1 prescribed medicine for fast, effective relief of allergic itch and inflammation due to atopic and allergic dermatitis 1 Indications Control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age. Six adult horses with a mean weight of 528 kg were . For years, glucocorticoids and cyclosporine have been used for the symptomatic management of atopic dermatitis, including the associated pruritus. By blocking cytokines, Apoquel blocks your dog's skin from itching and inflammation. Ultimately, my vet did not recommend we go down that route. These inhaled substances can trigger an allergic response that causes narrowing of the airways, mucous secretion, and cough., Luckily, minimizing common allergens in your horses environment could suffice to restore his comfort and breathing. IgE binds to cells in the body and releases inflammatory molecules. Allergies primarily affect the immune, respiratory, and integumentary (skin) systems and, if unmanaged, can seriously impact an animals performance and well-being. In cats, this medication can cause excitement rather than sedation. Apoquel 10. Discount Prices on Pet Supplies, Nexgard, Bravecto, Trifexis, Simparica TRIO, Apoquel, and more. Its an annoying pill schedule to keep track of, but my boarding barn has been great about it. 1,2 For over 30 years, Adequan i.m. Webcast | Then reintroduce each, one by one, while monitoring for hives or other signs of allergies. Vet Dermatol 2019;30(2):110-e30. Apoquel is a prescription dog allergy medicine used for the control of itch associated with allergic dermatitis and control of atopic dermatitis in dogs 12 months and older. Dexamethasone commonly is used in horses to treat allergic reactions such as respiratory allergies, chronic obstructive pulmonary disease (heaves), hives, itching and inflammatory diseases including arthritis. That something could very well be allergy-induced asthma. 11. Blood was collected prior to drug administration and at 15 min, 30 min, 45 min, 1, 2, 4, 6, 8 . Vet Dermatol 2013;24:48-e12. Nevertheless, these data should be taken with caution, and only as an approximation, because there is no basic information on the . Apoquel reduces dog itch, and also decreases inflammation, redness, or swelling of the skinso your dog feels better as quickly as possible What is Apoquel Tablet? Milder cases of asthma are still associated with coughing, airway inflammation, mucous production, and poor performance.. This gives you the total number of milligrams for the dose for your horse. This content is intended for counseling purposes only. Natural Disaster: Are You and Your Horse Ready for Emergency Evacuation? Thank you! J Zoo Wildl Med 2017;48(3):818-828. Vet Dermatol 2016;27(1):22-e7. The biggest disadvantages are the cost, the need to acclimate the horse to having the device placed in his or her nostril, poor tolerance by some horses who dislike the device, and the uncertainty about how long your horse will be able to go without repeating the treatment. Weve been doing really well with every other day dosing. 12. The downside is that it can cause laminitis and can suppress their immune system. Anecdotal reports indicate that oclacitinib is not very effective in managing recurrent and/or chronic otitis and interdigital furunculosis associated with allergies, and a sudden loss of efficacy is often associated with bacterial or. Let's look at the differences between these two medications, as well as some other treatment options for your dog's allergies. ACVIM, a Florida-based large animal internal medicine specialist with an interest in respiratory disease. Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy and quality of life. 3. Horse dosing is 5 pills. Interestingly, the results suggest that oclacitinib has immunosuppressive properties, but only at a higher dosage than that approved on the label.30. Collard WT, Hummel BD, Fielder AF, et al. Really? Apoquel is an anti-itch tablet given twice daily for the first . J Vet Pharmacol Ther 2014;37(4):317-324. Vet Dermatol The second option is serum (blood) testing. Apoquel Dosage for Dogs. Breeding and Reproduction Horse breeding from planning through foal care; Diseases and Conditions Horse-health-problem risk factors, prevention, diagnosis, and treatment; Farm and Barn . The efficacy and safety of oclacitinib have been assessed in various studies. 1. The frequency of urinary tract infection and subclinical bacteriuria in dogs with allergic dermatitis treated with oclacitinib: a prospective study. Adv Vet Dermatol 2017;8:192-198. Vet J 2016;207:29-37. Transdermal applicator that gives easy & accurate dosing every time. Apoquel for Dogs: Understanding the Uses, Side Effects, and Dosage for Simpson AC, Schissler JR, Rosychuk RAW, et al. With an online account, access our extensive formulary or over 40,000 unique items - 24 hours a day, 7 days a week. 27. Panteri A, Strehlau G, Helbig R, et al. Cochet Faivre N, Degorce-Rubiales F. Clinical eosinophilic popular dermatitis associated with histological eosinophilic granuloma rapidly responsive to oclacitinib in an adult Labrador retriever. I havent noticed any abnormal side effects. Vet Dermatol 2018:29:371 (abstract). Apoquel can be administered with or without food. How Organized Are Your Horses Health Records? If you struggle to get your dog to take tablets, you can try hiding it in their food, or wrapping it in a tasty piece of meat. Pruritus is a common clinical sign in allergic skin diseases. Proc (Bayl Univ Med Cent) 2018;31(4):524-525. This treatment option is FDA approved for equine asthma, and is very safe with no known side effects. Apoquel Tablet | Free 2 Day Shipping | WalmartPetRx.com Feline idiopathic ulcerative dermatosis treated successfully with oclacitinib. Apoquel For Dogs: The Best Allergy Medicine For Dogs? Dosage Chart These animals require the opposite regimen. not random, very relevant and helpful! 12. Gonzales AJ, Humphrey WR, Messamore JE, et al. Cochet Faivre N, Degorce-Rubiales F. Clinical eosinophilic popular dermatitis associated with histological eosinophilic granuloma rapidly responsive to oclacitinib in an adult Labrador retriever. Immunomodulatory in vitro effects of oclacitinib on canine T-cell proliferation and cytokine production. Chlorpheniramine Maleate | VCA Animal Hospital Its expensive, but its working. These reports suggest the potential use of oclacitinib in other diseases; however, it cannot be stressed enough that the use of oclacitinib in these diseases is an off-label use. Successful treatment of atopic dermatitis with the JAK1 inhibitor oclacitinib. Copyright 2023 Today's Veterinary Practice Web DesignbyPHOS Creative. View more. 14. The mare luckily didnt have a lot of food allergies and eliminating flax wasnt a big deal. The recommended Apoquel dosage for dogs is 0.18 to 0.27 mg per lb of body weight (0.4-0.6 mg/kg) once a day. Apoquel is sold per tablet in strengths of 3.6 mg, 5.4 mg, or 16 mg. Dosage and Administration: The dose of APOQUEL (oclacitinib maleate) tablets is 0.18 to 0.27 mg oclacitinib/lb (0.4 to 0.6 mg oclacitinib/kg) body weight, administered orally, twice daily for up to 14 days, and then administered once daily for maintenance therapy. I am not saying it is a cure all, but that and some generic Zyrtec make my mare a whole lot more comfortable. Dosage and administration For oral use. These and other kinase-inhibiting drugs sometimes work very well to stop the itching. The Janus kinases (Jaks). We have been using an inflatable fleece e-collar on her . This might, down the road, be an easier and less expensive alternative for horse owners. 21. holy crapola batman- just had to put my dog back on it (Hes usually on it April through Nov but with the weird weather we got away with waiting until July thankfully) and saw the price increase- yikes! . Collard WT, Hummel BD, Fielder AF, et al. All rights reserved. In this study, 70% of the study population receiving oclacitinib showed improvement in pruritus compared with 75% in a group receiving methylprednisolone.18 Based on this study, a higher dose with a longer induction period seems to be the key to successfully treating feline pruritus with oclacitinib. Oclacitinib is available in 3 different tablet sizes: 3.6, 5.4, and 16 mg. Both can be very serious. Vercelli A, Cornegliani L. Use of oclacitinib in treatment of canine idiopathic ear tip vasculitis. Gonzales AJ, Bowman JW, Fici GJ, et al. Apoquel for Dogs: How it Works, Benefits, Dosing, and Safety Why were losing our horse doctors and how to begin solving the problem. Frank RK, Galvan BA, Schoell AR, et al. Derm Dialogue - Fall 2019 by TEAM - Issuu She is a New-York-based freelance author with a passion for equine health and veterinary care. Lucile Vigouroux holds a masters degree in Equine Performance, Health, and Welfare from Nottingham Trent University (UK) and an equine veterinary assistant certification from AAEVT. I had my dog on it and the price was pretty steep. She then completed a 1-year rotating small animal internship in Massachusetts followed by a 3-year veterinary dermatology residency in Georgia. Several reports of successful use of oclacitinib to treat other diseases have been published. Ordering patient medications is easy. Ive used it on a couple of mine, and I also have some friends who have done it. It is initially prescribed twice daily for 14 days, then once daily for maintenance therapy. The dose of Apoquel tablets is 0.18 to 0.27 mg/lb of body weight. Equine Drug Dosage Calculations | Equimed - Horse Health Matters Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis. Little PR, King VL, Davis KR, et al. Rarely, dogs on Apoquel develop new skin masses; however, a long-term study found no association between Apoquel and the development of malignant cancer. In the first 2 randomized, double-blinded, placebo-controlled clinical trials, it was shown that oclacitinib, given at a dose of 0.4 to 0.6 mg/kg q12h, induced a rapid reduction in pruritus and treatment success in 62.3% to 67% of treated cases within 7 to 14 days. See full Excede for Swine Prescribing Information. Since the vast majority of Equine Asthma patients do not have a histamine-associated problem, this isn't likely to work for most. Oclacitinib: Treating Pruritus and Beyond - Today's Veterinary Practice A follow-up study assessed the long-term safety, efficacy, and quality of life of oclacitinib-treated dogs. Vercelli A, Cornegliani L. Use of oclacitinib for the treatment of acral lick dermatitis in a dog: a case report. A newer prescription drug, Apoquel (oclacitinib) has recently hit the market and might prove useful for allergic horses. When your dog is itchy, you get desperate to make him feel more comfortable. Vet Dermatol 2014;25:153 (abstract). Use code GOODRX20 Sponsored by Avoid giving the medicine twice daily long-term. Vet Dermatol 2016;27(Suppl 1):100 (abstract). Veterinarians are especially wary of administering corticosteroids to allergic horses that suffer from pituitary pars intermedia dysfunction, insulin dysregulation, and/or equine metabolic syndrome, because these conditions are also risk factors for laminitis. Vet Dermatol 2013;24(5):479-e114. The onset of efficacy for oclacitinib is up to 1 week, but Little et al found that after 4 weeks of treatment, both drugs demonstrated comparable control of clinical signs. Adverse events were reported in less than 5% of dogs, including urinary tract infection, vomiting, otitis, pyoderma, and diarrhea.9 A subsequent study concluded that there is no increased risk for urinary tract infections.10, The efficacy of oclacitinib was also compared to that of other drugs such as prednisolone and cyclosporine. In a 3-week trial, the combination of oclacitinib and cyclosporine did not show an increased risk for adverse effects.13, Anecdotal reports indicate that oclacitinib is not very effective in managing recurrent and/or chronic otitis and interdigital furunculosis associated with allergies, and a sudden loss of efficacy is often associated with bacterial or Malassezia overgrowth.14 Sudden withdrawal from oclacitinib can also result in a rapid return of clinical signs, which sometimes appear more severe than before treatment.15, Most recently, it was suggested that the treatment strategy for canine atopic dermatitis might need to be adjusted. Apoquel For Dogs: Side Effects And Safety - Dogs Naturally